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Clinical trials that are designed to help inform practice in the real world are called pragmatic trials. They are often characterized as a focus on the practical aspects of design which include the recruitment and consent process, as well as adherence and the use of routinely available equipment.

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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This type of heterogeneity, which is vital for a pragmatic trial to be valid and to reduce bias in the results, is also necessary. However too much heterogeneity could result in problems with the design of the trial.

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The aim of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are typically commissioned by practitioners and policy makers to guide their decision-making. They can also be used to determine the causal relationship between an intervention and its effects. However, 프라그마틱 정품확인방법 they should not be used as a substitute for explanatory trials.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials should replace or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory studies, 라이브 카지노 [http://idea.informer.com/users/lambhen8/?what=personal] which prove the physiological hypothesis or clinical hypothesis, as well as pragmatic trials that aid in the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the elements of a pragmatic study which includes recruitment, design, 프라그마틱 무료스핀 delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs), returned 34 articles. These are highlighted in red on Figure 2. This indicates that the health science community is becoming increasingly sensitized to the issue of pragmatism. It is important to keep in mind, however, that the majority were conducted in primary care settings.