Macrophages and dendritic cells use similar mechanisms for processing and presentation of antigens and their epitopes in association with MHC II; B cells use somewhat totally different mechanisms that will likely be described additional in B Lymphocytes and Humoral Immunity. For now, we will deal with the steps of the process as they pertain to dendritic cells. After a dendritic cell acknowledges and attaches to a pathogen cell, the pathogen is internalized by phagocytosis and is initially contained within a phagosome. Lysosomes containing antimicrobial enzymes and chemicals fuse with the phagosome to create a phagolysosome, where degradation of the pathogen for antigen processing begins. APCs don't current all potential epitopes to T cells; only a number of the most antigenic or immunodominant epitopes are introduced.

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