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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are often described as a focus on the practical aspects of study design which include recruitment and consent, adherence and the use of routinely available equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which used a variety of investigators and included participants from different geographical regions. This kind of heterogeneity is necessary for pragmatic trials to be valid and reduces bias in the results. Too much heterogeneity, however can result in problems with the trial design.

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Pragmatic Play has gained a reputation for offering top-notch games and an exceptional user experience. Its software is designed to work on mobile devices and is compatible with multiple languages. Despite its relatively young age, it has already established itself as a leading casino gaming platform. Wolves is one of its latest releases, a 5-reel slot machine that has a high RTP and stunning graphics. Other notable titles include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to simulate real-life scenarios and gain maximum validity externally. They are typically commissioned by practitioners and policy makers to inform their decision making. They can be used to determine the causal relationship between an intervention and its results. However, they shouldn't be used to substitute for explanatory studies.

The pragmatism concept is controversial and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested the distinction between explanatory trials, which prove a physiological or clinical hypothesis, and pragmatic trials, which guide the policy and practice of. They also suggested a framework dubbed PRECIS for pragmatic trials.2 This tool tried to define the characteristics of a pragmatic research study, including recruitment, design, delivery of the intervention and follow-up.

The number of pragmatic trials is increasing. A recent Medline query using the keywords pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatics. It is important to keep in mind that the majority of these studies were conducted in primary care settings.