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Trials designed to inform clinical practice in the real world are referred to as pragmatic trials. They are often described as a focus on the practical aspects of designing a study that include recruitment and consent, adherence and the use of standard equipment.

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Pragmatic is a software company offers a range of casino games on online gambling platforms. Pragmatic's iGaming software is used by top operators and land based casinos. The company offers front-end website design tools, analysis tools and marketing, promotions, security, payment systems, customer service and bug reporting. The company also offers security, high-quality graphics, gaming and security.

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Another example of a trial that is pragmatic is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and included participants from various geographical areas. This type of heterogeneity that is crucial for pragmatic trials to be reliable and to reduce bias in the results is also essential. However, too much heterogeneity can result in problems with the design of the trial.

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Pragmatic trials seek to replicate real-life settings and achieve maximum external validity. They are usually commissioned by practitioners and policy makers to guide their decision-making. They can also be a great way to identify the causal relationship between an intervention and its outcomes. However, they should not be used in lieu for explanatory trials.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which confirm the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide policy and practice decisions. They also suggested a framework for 프라그마틱 홈페이지 pragmatic trials, dubbed PRECIS.2 This tool attempted to define the elements of a pragmatic trial which includes the recruitment process, the design and implementation of the intervention, as well as the follow-up.

There is an encouraging increase in the number of pragmatic trials that have been published. A recent Medline search using the terms pragmatic and naturalistic, restricted to controlled trials randomized to control (RCTs), yielded 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more acquaint to the subject of pragmatic thinking. It is important to remember that the majority of studies were conducted in primary care settings.