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Trials designed to inform clinical practice in the real world are called pragmatic trials. They are often described as a focus on the practical aspects of design, including the recruitment and 프라그마틱 정품확인 무료체험 슬롯버프 (visit Freebookmarkpost here >>) consent process, as well as adherence and the use routinely available equipment.

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A pragmatic study that involves a variety investigators and includes participants from different geographical areas is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity is essential for pragmatic trials to be valid and reduces the chance of bias in the results. However too much heterogeneity could cause issues with the design of the trial.

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The goal of pragmatic trials is to simulate real-life scenarios and to achieve maximum credibility externally. They are typically commissioned by policymakers and practitioners to guide their decisions. They can also be a great way to identify the cause-effect relationship between the intervention and its effects. However, they should not be used in lieu for the use of explanation trials.

The concept of pragmatism is controversial, and there are questions about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and 프라그마틱 정품 pragmatic trials, which guide the practice and policy decisions. They also suggested a framework known as PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study that includes recruitment, design, delivery of the intervention, and follow-up.

There is a positive increase in the number of pragmatic trials that are published. A recent Medline search using the terms naturalistic and pragmatic, which was limited to controlled trials randomized to control (RCTs), yielded 34 articles, shown in red in Figure 2. This is an indication that the health sciences community is becoming increasingly sensitized to the issue of pragmatism. It is important to note that the majority of these studies were conducted in primary care settings.